Cancer genetic news, Testarea genetică la cancerul mamar și ovarian - Invitro Diagnostics

Department of Molecular Virology

The researchers have proved the anti-tumor effects of the drug on immunodeficient mice. The new compound and its derivatives enabled the researchers to reduce tumor activity by 50 percent after 41 days of treatment with the drugadministered twice a week, to mice with induced tumors.

They have also managed to successfully describe the mechanisms by which the drug acts on cancer genetic news cancer stem cells CSCs.

Predispozitia genetica in cancerul de san si cancerul ovarian 5 Mar Inapoi la articole Toate femeile sunt expuse riscului de a dezvolta cancer de san sau cancer ovarian de-a lungul vietii, insa, unele femei au un risc suplimentar, adesea din cauza factorilor genetici, pe care nu ii pot controla. Cancerul de san este mai putin frecvent la femeile mai tinere, dar femeile tinere au mai multe sanse sa aiba cancer de san ereditar, cauzat de o anomalie genetica mostenita.

The Córdoba-based company Canvax Biotech has also participated in the development of the patent. A non-toxic drug One of the major advantages of the drug is that it is non-toxic.

Despite being administered to the mice in high concentrations milligrams per kilono adverse effects were observed in the healthy cells.

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Moreover, from a pharmaceutical perspective this anti-tumor drug can be successfully produced in large quantities. The researchers were able to obtain the required amount of the synthesis in just five days.

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In the initial phases of their research, the scientists had already managed to create an effective drug called Bozepinib for treating cancer stem cellsbut the process involved in its chemical synthesis was lengthy and required a great deal of time to produce very small quantities of the drug.

Having completed structural modifications of the drug—Bozepinib by making changes to its cancer genetic news architecturethey have successfully created a compound which maintains the biological activity of its predecessor as an effective anti-tumor drug, but which can also be synthesized and produced on a grand scale—a fundamental condition cancer genetic news the drug's commercial development.

Hereditary cancers and genetic testing: Mayo Clinic Radio

In order to be able to test the new drug on mice and gauge its effectiveness on human tumors, first of all they had to inject human tumor cells into immunodeficient mice to ensure they did not reject these cancerous cells.

Following the treatment, cancer genetic news discovered that some of the compounds effectively inhibited the growth of the tumor cells and the migration ability of these cells to other healthy tissues, considerably diminishing the likelihood of metastasis.

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The drug directly targets CSCs without affecting the healthy cellsa huge advantagewhen compared to other cancer treatments such as chemotherapy. AlthoughCSCs are only found in small quantities in tumors, from a clinical perspective the ability to target them directly is of fundamental importance, given that they are responsible for originally causing the tumor, relapses and resistance to anticancer treatments.

The next step: Lungs and pancreas Having proved the pre-clinical effectiveness of the new drug in treating cancer stem cells in breast, colon, and skin cancers, the scientists will now proceed to study the candida cu condilom effect on lung cancer genetic news pancreas cancers, two of the most aggressive types. They must also complete further ADME-Tox "absorption, distribution, metabolism, excretion and toxicity" studies of the compound's behavior within the organism, a necessary step before carrying cancer genetic news clinical trials.

RSC Adv.

BRCA+16 GENES - predispozitia ereditara pentru cancerul de san, ovar si endometru

García-Rubiño, M. Núñez-Carretero, D. Choquesillo-Lazarte, J.

Agentii cancerigeni pot fi naturali, cum este aflatoxina, care este produsa de o ciuperca si uneori se gaseste pe cereale sau pot fi creati de om, cancer genetic news azbestul sau fumul de tutun. Expunerea la azbest, in special la angajatii din mediul industrial, a fost puternic legata de dezvoltarea unui tip specific de cancer pulmonar numit mezoteliom malign. Carcinogenii interactioneaza cu ADN-ul unei celule si induc mutatii genetice. Acest lucru duce, in final, la formarea unei tumori o crestere anormala a tesuturilor care are capacitatea de a se raspandi metastazade a invada si de a provoca disfunctii ale altor tesuturi, culminand cu insuficienta organelor si decesul persoanei. Exista doua mecanisme primare prin care agentii cancerigeni initiaza formarea tumorilor: Producerea unor modificari ale ADN-ului care stimuleaza diviziunea celulara si care impiedica celulele sa se poata autodistruge atunci cand sunt stimulate de declansatori normali, cum ar fi deteriorarea ADN-ului sau leziuni celulare un proces cunoscut ca apoptoza.

García-Ruiz, Yolanda Madrid, J. Campos, Ana Sánchez, María A.

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García, Juan A. Oncotarget,5 11 Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.