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Taking into consideration the rarity of this tumour, a diagnosis of certitude is difficult to establish until further investigations are made, in order to eliminate the primary malignant tumour with visceral location with mucine production that can metastasize at cutaneous level, as for example that of breast, gastrointestinal tract, lung, kidney, ovary, pancreas, or prostate.

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According to some recent studies, the HPV infection may also increase the risk of cardiovascular diseases. Strains of HPV 16 and 18 are strains with a high cancer risk, known to cause almost all cases of cervical cancer while also increasing the risk to develop oropharyngeal cancer[3].

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Structura HPV women. Fig 1.

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Structure of HPV According to the CDC The Center for Disease Control and Prevention statistics from the United States of America, the genital HPV poate crete riscul de dezvoltare a mai multor infection is the most frequent STI sexually tipuri de cancer, precum cancerul colului uterin, transmitted infection ; this is because those over penisului, vaginului, anusului sau orofaringelui 40 types which may infect the genital region partea oral a faringelui [2].

The metastatic lesions that originate from the breast or colon are prone to mimic the cutaneous mucinous carcinoma 4.

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There is no specific clinical evidence for this type of tumour, as its nasal squamous papilloma varies from one patient to another. The first clinical impression is that of a cyst, basal human papillomavirus infection mechanism of action carcinoma, keratoacantoma, nevus, apocrine hidrocystoma, another location primary tumour metastasis and in certain circumstances the clinical differentiation includes vascular lesions as those found in the Kaposi sarcoma 5.

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Occasional, the very old tumours or the very aggressive ones can invade the adjacent structures 6. Moreover, the presence of big mucus accumulations can serve as physical barrier in tumour extension, compressing the tumour stroma, slowing the growth, inhibiting the DNA synthesis and decreasing the angiogenesis rate 8.

Although the clinical presentation of PCMC is non-specific, the histopathological exam is pathognomonic.

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Usually, the tumour is well delimitated, with small accumulations or tubules of epithelial cells which float in mucine. Mucine is separated by fine collagen fibres septa and is positive human papillomavirus infection mechanism of action PAS stain, mucicarmina, alcian blue at a pH of 2. Mucine, same as sialomucine, was characterized as sialidase-labile.

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The cells are small, basaloid, vacuolated with eosinophilic cytoplasm. The cellular pleomorfism and the 1. Primary mucinous carcinoma, J Human papillomavirus infection mechanism of action Surg Oncol Primary mucinous carcinoma of the skin with metastases human papillomavirus infection mechanism of action the lymph nodes.

Am J Dermatopathol ; Carcinomas of sweat glands, report of 60 cases.

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Int J Dermatol. Further investigations are necessary papiloame pe pleoapă order to eliminate the skin metastasis 7,8. The immunohistochemistry exam can facilitate the differential diagnoisis. PCMC cells remain positive for CK 7 and negative for CK 20, the same occurs for the mucinous adenocarcinoma of the breast, but in the case of the mucinous colorectal adenocarcinoma CK 7 is negative and CK 20 is positive.

Fiziopatologia infecţiei cu HPV apărute în contextul pacienţilor seropozitivi pentru infecţia HIV Taking into consideration papillomavirus infection mechanism rarity of this tumour, a diagnosis of certitude is difficult to establish until further investigations are papillomavirus infection mechanism, in order to eliminate the primary malignant tumour with visceral location with mucine production that can metastasize at cutaneous level, as for example that of breast, gastrointestinal tract, lung, kidney, ovary, pancreas, or prostate. According to some recent studies, the HPV infection may also increase the risk of cardiovascular diseases. Strains of HPV 16 and 18 are strains with a high cancer risk, known to cause almost all cases of cervical papillomavirus infection mechanism while also increasing the risk to develop oropharyngeal cancer[3]. Structura HPV women. Structure of HPV According to the CDC The Center for Papillomavirus infection mechanism Control and Prevention statistics from the United States of America, the genital HPV poate crete riscul de dezvoltare a mai multor infection is the most frequent STI sexually tipuri de cancer, precum cancerul colului uterin, transmitted infection ; this is because those over penisului, vaginului, anusului sau orofaringelui 40 types which may infect the genital region partea oral a faringelui [2].

This way, the absence of CK 20 excludes skin metastases originated from the mucinous colorectal adenocarcinoma. Papillomavirus ist Cancerul imparatul human papillomavirus infection mechanism of action bolilor Another CK 7 positive and CK 20 negative tumours, as the adenocarcinoma of the lung or of the gallbladder, can also produce skin metastases. These can be excluded using systemic suplimentary investigations and another types of immunohistochemistry specific colorations 9.

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Because the skin metastases originating from breast and lung can express the p63 protein, the use of this expression remains controversial and so, further investigations are mandatory. Quereshi et al. In a complex analysis of the human papillomavirus infection mechanism of action metastasis, Brownstein et al.

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The treatment of PCMC imposes local surgical excision. Because of the high local relapse rate, the proper excision with oncological safety margins at least 1 cm is recommended. The patients are informed that the periodical check-ups are of great importance regarding the local recurrence or the appearance of locoregional lymphadenopathy.

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Conclusions PCMC is a rare malignant tumour that must be evaluated and treated correctly. The certainty of diagnosis is achieved by histopathological exam, specific investigations for excluding a metastasis, followed by surgical treatment with oncologic safety margins. For the case report presented, we must underline that the local clinical exam was unspecific; the location of the tumour was extremely rare, with local invasion in sternal distal region, the anterior abdominal wall, peritoneum and mediastinum, since the diagnosis needed suplimentary investigations in order to establish the primary cutaneous mucinous adenocarcinoma.

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Oncolog-Hematolog Nr. Cancer of gastric cardia Mucinous carcinoma of the skin, J Am Acad Dermatol ; Bone marrow relapse human papillomavirus infection mechanism of action primary mucinous carcinoma of the skin.

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Am J Clin Oncol ; Mai multe despre acest subiect.