Neuroendocrine cancer with liver mets, Journal of Gastrointestinal and Liver Diseases

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Neuroendocrine cancer - loredanaliliungureanu - Pancreatic neuroendocrine tumors - Neuroendocrine cancer with liver mets Conținutul The liver represents the preferential site for neuroendocrine tumors' metastases. Case presentation: A year old Caucasian female who presented with nausea, vomiting, diarrhea, accompanied by diffuse abdominal pain was found to have on contrast-enhanced computer tomography an encapsulated, partially cystic liver mass.


The patient underwent an uneventful left atypical hepatic resection. Histopatological and immunohistochemical examination revealed a slowly growing G1 hepatic neuroendocrine tumour.

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Post surgery, the specific neuroendocrine markers serum Chromogranin A and 24h urinary 5 hydroxy-indolacetic acid were within normal range. Further functional imaging investigations were performed.

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The patient is presently after 4 years of follow-up with no local recurrence or distant metastases. Conclusions: The diagnosis of PHNET is a medical challenge that requires a thorough longterm follow-up in order to exclude an occult primary neuroendocrine tumour. Key words: neuroendocrine tumor - primary hepatic neuroendocrine tumor - chromogranin A.

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