This study was performed to evaluate the clinical risk profile of patients with ovarian tumors who were surgically treated, measuring the survival rate at 5 years. Furthermore, the surgical treatment by TNM stages was achieved, measuring the survival rate after five years of follow-up. Most of the patients with malignant disease were multiparous Moreover, from menopausal patients, the higher prevalence was seen at the group between 45 and 55 years old, not being dependent on the earlier appearance.
The highest incidence of gynecological pathology was seen in women with polycystic ovaries i. Regarding serum CA tumoral marker, higher values were noticed in the majority of patients The highest prevalence of surgical treatment in the first and second stages was represented by total hysterectomy with bilateral anexectomy, omentectomy and peritoneal lavage, and for the third and ovarian cancer under 25 stages, total hysterectomy, bilateral anexectomy, omentectomy, peritonectomy and lymphadenectomy, with a better survival rate at five years seen in patients under the age of 30 years old.
Thus, our study shows the need to create a screening for patients at risk for ovarian cancer which present higher age, multiparity, early menarche, polycystic ovaries association, and higher serum CA marker values.
The survival rate at five years of folow-up shows a higher incidence of survival in patients under 30 years old, probably due to the earlier stages detected.
Clinical risk profile associated with ovarian cancer
Keywords malignant tumors, ovarian cancer, surgical treatment, management Rezumat Context. Acest studiu a fost efectuat pentru a evalua caracteristicile profilului de risc clinic al pacientelor cu tumori ovariene care au fost tratate chirurgical, măsurând rata de supravieţuire la cinci ani.
Mai mult, a fost realizat tratamentul chirurgical prin etapele TNM, măsurând rata de supravieţuire după cinci ani de urmărire. Mai mult, din de paciente la menopauză, prevalenţa crescută a fost observată la grupul cuprins între 45 şi 55 de ani, fără a depinde de precocitatea apariţiei.
CA markeri tumorali
Prevalenţa crescută a tratamentului chirurgical în stadiile I şi II a fost reprezentată de histerectomie totală cu anexectomie bilaterală, omentectomie şi lavaj peritoneal, iar pentru stadiile III şi IV, de histerectomie totală, anexectomie bilaterală, omentectomie, peritonectomie şi limfadenectomie, cu o rată mai mare de supravieţuire la cinci ani la pacientele cu vârsta sub 30 de ani.
Riscul apariţiei tumorilor ovariene maligne este asociat mai mult cu vârsta, paritatea, menarha timpurie, asocierea ovarelor polichistice şi ovarian cancer under 25 pe stadializarea TNM. Rata de supravieţuire la cinci ani ulterior arată o incidenţă mai mare a supravieţuirii la pacientele cu vârsta sub 30 de ani, probabil datorită detecţiei în stadiile incipiente.
Cuvinte cheie tumori maligne cancer ovarian tratament chirurgical management Introduction Being the leading cause of gynecological diseases, ovarian tumors are estimated as the fifth cause of death among women 1.
Many of the published studies are institutional-single center analyses which enrolled only a small number of patients and the majority of reports were not relating to general population 7,8.
Although many studies have been published about ovarian tumors, only a few have analyzed the importance of the clinical factors implicated 9.
And currently, only a limited number of studies regarding detailed surgical staging have been published, including the survival rate of younger women diagnosed with ovarian tumors Although for most of the early-detected cases the treatment consisted in total hysterectomy, infracolic omentectomy, peritoneal biopsy and lymph node extraction, maximal cytoreductive surgery remains the basic surgery esophageal papilloma histology for advanced ovarian tumors Besides many other ovarian cancer under 25 markers involved in diagnosis and prognosis of ovarian cancer, serum cancer antigen CA is generally used in the differentiation of other pelvic mases 16, This marker can be evaluated as a prognostic factor, before the initiation of any treatment However, the implication of serum CA levels in ovarian cancer prognostic is more controversial, considering other variabilies such as staging The present study was undertaken ovarian cancer under 25 ovarian cancer patients, in which we proposed to determine the risk associated with age, parity, menarche and menopause precocity, gynecological pathologies, serum CA tumoral marker, tumor, lymph node and metastasis TNM staging, and surgical treatment associated with improved five-year survival outcome.
Our study group consisted ovarian cancer under 25 patients with malignant ovarian tumors who were selected from a total of ovarian tumors which presented at least one ovarian tumor formation with a 5-mm minimal diameter. All patients underwent surgery as primary treatment.
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The study was approved by our institution, and the informed consent from each patient was taken. The inclusion criteria were as follows: age between 15 years old and more than 60 years old at the time of the initial diagnosis, all stages of ovarian neoplasms, and receiving only surgical treatment.
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We excluded women with a history of tubal sterilization techniques, pelvic radiation therapy either pre- or postoperatively, including pregnant women. The characteristics were expressed in percentages.
Descriptive statistics was used in order to correlate the data. Results Distribution by age Regarding the age of the patients, most malignant ovarian tumors were encountered in the age group over 60 years old, follwed by year-old patients, with Table 1. Distribution of cases with malignant ovarian tumors by age Parity of the patients Out of the studied women, Figure 1.
Distribution of cases Age of menarche Malignant ovarian cancer under 25 occurred in patients Figure 2. Distribution of cases with ovarian tumors depending Menopause precocity Of the cases analyzed, patients were menopausal, with the remaining 76 being in a younger age group.
Out of these, 44 Figure 3.
Profil estimare risc cancer ovarian (HE4, CA 125, scor ROMA)
Distribution of cases with ovarian tumors depending Association of gynecological pathology Malignant ovarian tumors were associated more with polycystic ovaries, in 13 patients 5. Table 2. Distribution of ovarian cancers studied according to associated gynecological pathology Figure 4.