Georges Marinesco : neurologist, neurohistologist and neuropathologist M. Catala, J. This ovarian cancer remission will forever imprint the mind of Marinescu, a great friend of France, a respectful student of Charcot and a friendly colleague of many Parisian neurologists. Marinescu's works are multiple and very important. He describes the succulent hand in syringomyelia and the palmar-jaw reflex.
Marinescu is also one of the first to use the cinema for medical purposes. His work as an anatomo-clinician, a method developed by Charcot, is important. We denote the description of the locus niger affected by tuberculosis in a case of parkinsonism this description paving Etienne Brissaud's way to highlight the anatomical origin of Parkinson's diseasethe original clinical description of Marinesco-Sjogren syndrome, and that of medullomyoblastoma.
Marinescu is also a famous neurocytologist as evidenced by his work, La Cellule Nerveuse, published in The first volume of the book is devoted to the aspects of the normal nervous tissue: the neurofibrillar network, the chromatophilic elements, and the paranucleolar corpuscles now known as Marinescu's bodies. The second volume of the book is almost related to features revealed by experimental lesions: chromatolysis and neuronophagia. Furthermore, Marinescu describes with Oscar Blocq, small nodules than are now regarded as the first description of senile plaques.
Immunohistochemical and morphologic evaluation of primary cutaneous apocrine carcinomas and cutaneous metastases from ductal breast carcinoma A. Fernandez-Flores The differential diagnosis between a primary cutaneous apocrine carcinoma CAC and a cutaneous metastasis from a breast carcinoma can be a very difficult task if it is only made on morphologic bases.
Ovarian cancer remission ovarian cancer remission tumors in generalthere have been many attempts to define an immunohistochemical panel, and while a definition is useful in certain respects, the series presented often times does not include examples of CAC. Other times, CAC seems to behave in an odd way in an immunohistochemical context; they behave differently ovarian cancer remission other adnexal tumors, and this in turn adds a grade of confusion to the differential diagnosis papilloma 58 ovarian cancer remission cutaneous metastasis.
In the current study, we include seven cases of primary cutaneous apocrine tumors, including one carcinoma in situ, five infiltrating carcinomas, and one adenoma. Additionally, we examine the expression of ovarian cancer remission receptors ERprogesterone receptors PRand c-erbB Mammaglobin was a very useful marker, expressed by Regarding the expression of c-erbB-2, all of our cases had a value of either 0 or 1.
Whole-genome DASL gene expression profiling of hepatocellular carcinoma sub-populations isolated by laser microdissection on formalin-fixed and paraffin-embedded liver tissue samples Corina Gabriela Cotoi, Shirin Elizabeth Khorsandi, I. Plesea, A. Quaglia In the last ten years, a multitude of studies focusing on gene expression profiling have attempted to shed light on the molecular and genomic mechanisms leading to hepatocarcinogenesis.
Recent advances have made it possible to obtain good quality RNA from formalin-fixed paraffin-embedded FFPE tissue, allowing access ovarian cancer remission a virtually limitless archival resource to be available for retrospective and long-term prospective clinico-pathological studies.
What determines ovarian cancer patient response to treatment and survival?
Laser-capture microdissection allows the ovarian cancer remission of specific cell populations or of specific microscopic areas of interest from tissue samples. This allows the selective evaluation of gene expression of targeted cell clusters, especially in a very heterogeneous environment as the malignant tissue. A large number of genes were expressed in both subpopulations of hepatocellular carcinoma classical HCC and cholangiocellular differentiation as well as in the cirrhotic and non-cirrhotic liver background.
Taisescu, R. Stanescu, Mihaela Hincu, Stefania Craitoiu, Ileana Monica Banita VEGF is one the pro-inflammatory adipokines synthesized by the "adipose secretoma" of obese subjects as a response to hypoxic conditions; but the main function of VEGF is angiogenesis, being recognized as the most important factor increasing blood capillaries in the adipose tissue by stimulating endothelial cell growth. In this paper, we propose a comparative study of the vascular response to VEGF synthesis in simptome detoxifiere organism subcutaneous and central-peritoneal adipose depots in lean, obese and obese diabetic ovarian cancer remission.
We used CD31 to label the endothelial cells in order to evaluate the response of the vascular network to VEGF synthesis. Our results showed an increase of VEGF protein synthesis in obese and obese-diabetic patients compared to lean subjects where the protein was absent.
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The positivity for VEGF in obese diabetic samples was observed in numerous structures from the adipose depots, both in the stromal vascular fraction - blood vessels and stromal cells - as well as in doctor îndepărtând papilomele cytoplasm of adipocytes. Positivity in the vascular wall was observed more frequently in areas of perivascular and intralobular fibrosis.
Obese and diabetic patients showed similar incidence of CD31 immunoreactivity with lean subjects in both subcutaneous and peritoneal depots. In conclusion, human adipose depots show a different incidence of VEGF positive cells in relation with their ovarian cancer remission and the metabolic status.
VEGF synthesis in visceral adipose tissue is inefficient being not followed by angiogenesis to counterbalance tissue hypoxia. We suggest that may be a pathogenic link between the degrees of intralobular fibrosis in adipose depots and VEGF expression. Melinte, I. Jung, Lia Georgescu, Simona Gurzu Purpose: To determine the histological differences and the particular aspects of local medicament parazitar intex in knee joint of the patients with osteoarthritis OA and rheumatoid arthritis RA.
All surgical samples provided from total knee joint arthroplasty. Angiogenesis was quantified in both synovial membrane and cartilage. Results: In patients with OA, ovarian cancer remission proliferation of the synovial membrane was more prominent that in RA. In the last, invasion of the cartilage by the proliferated synovial tissue was more characteristic. The neovascularization was more intense in RA than in OA, in both synovium and degenerated cartilage. In RA, the vessels were immature in the superficial areas and became larger in the deep synovium.
The local angiogenesis was characterized by sprouting and splitting intussusceptions mechanisms.
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In OA, the mature vessels predominated in the subintimal zones. Sprouting or non-sprouting mechanisms of local angiogenesis, which can indicate vascular formation from the resident mature vessels, were not identified in OA. In RA, local active angiogenesis seems to predominate but in OA up taking of the circulating precursors may be more intensely involved. Intra-articular inhibition of local angiogenesis could have therapeutically impact in RA but not in OA. Finally, we can conclude that there probably are many different pathways leading to the same ovarian cancer remission damage having certain therapeutic consequences.
Pop, Anca Ovarian cancer remission We studied the clinical and histopathological changes in twenty-seven cases of acute ischemic stroke, aged between 65 and 75 years. All deaths occurred within 30 days after stroke.
The aim of our study was to establish the clinical and histological correlations in acute ischemic stroke to detect prognostic factors.
Brain lesions after acute stroke were observed in all regions. Our study describes the heterogeneity of brain injury after acute ischemic stroke with the participation of all brain components and the chronology in which these lesions develop and evolve. By histological and immunohistochemical studies, we identified neuronal, glial and vascular damage. The neurons had undergone in the ovarian cancer remission of lesion a process of necrosis, ballooning or condensation process.
In the ischemic penumbra, we observed the presence of red neurons. Vascular lesions were represented by the discontinuity of capillaries, always associated with a marked perivascular edema. The following clinical and morphological correlations were established: liquefactive necrosis, astrocyte gliosis, phagocytosis phenomena are the more intense the later the death of the patient; apoptosis phenomena are the more intense the faster the death of the patient; ovarian cancer remission entire cerebral microcirculation presented microscopic modifications following the ischemic strokes, regardless of the time since the lesion occurred and the histological examination was made; the major neurological complications of the ischemic stroke - the hemorrhagic transformation phenomena, cerebral edema, were microscopically objectified, regardless of the time since the lesion occurred and the histological examination was made.
The value of the histopathologic examination in the diagnosis and management of the actinic keratosis Alina Maria Vilcea, I. Vilcea, Claudia Valentina Georgescu, V. Patrascu Actinic keratosis, considered lately as an intraepithelial squamous cell carcinoma in evolution, are powerful predictors of the risk for developing a cutaneous carcinoma and melanoma.
The aims of the study were to establish the value of the histopathologic examination as a confirmation method for the actinic keratosis diagnosis, to assess the percentage of these lesions that suffer a malignant transformation, and also the frequency of the association between actinic keratosis and cutaneous carcinomas.
This is a retrospective study, performed on patients diagnosed with different types of cutaneous precancers, hospitalized in Dermatology Clinic of Craiova, Romania, between and Actinic keratosis represented Patient's age ranged from 17 to 85 years, The most frequent form was hypertrophic actinic recenzii cu gel de papilom In conclusion, actinic keratosis are the most frequent cutaneous precancer, diagnosed in chronic sun-exposed patients, and manifest a tendency to progress into a squamous cell carcinoma without a proper treatment.
Pathologic evaluation is mandatory to an accurate assessment of the actinic keratosis prevalence, and for the right management of these lesions.
Surface characteristics of retrieved coated and nickel-titanium orthodontic archwires Georgeta Zegan, Alina Sodor, C. Results: Initially, the orthodontic archwires showed microscopic manufacturing and coating defects in the physiognomic layer. After intra-oral exposure, amorphous organic matter deposits ovarian cancer remission observed on the surface of the NiTi Archwires and the wire coating presented exfoliation on the oral areas of friction with brackets.
X-ray microanalysis revealed changes in all atomic and mass percentages of chemical elements from the surface of all retrieved dental archwires, nickel and titanium ion depletion and the occurrence of additional elements due to interactions with saliva. Conclusions: Intra-oral exposure of NiTi Archwires and the ovarian cancer remission friction of coated wire altered the morphology and changed the elemental composition of the surface due to the process of corrosion, adhesion of organic matters and ionic exchange with oral fluids.
Correlations between intratumoral interstitial fibrillary network and tumoral architecture in prostatic adenocarcinoma A. Stoiculescu, I. Plesea, O. Pop, D. Alexandru, M. Man, M. Serbanescu, R. Plesea The authors made a preliminary assessment of possible correlations between the amount of intratumoral stromal fibrillary components ISFC and the architectural tumoral patterns described by Gleason.
The studied material consisted of samples obtained by transurethral resection from 34 patients diagnosed with prostatic adenocarcinoma.
Ten fields, five for dominant and five for secondary identified patterns of each ovarian cancer remission, with no necrosis were selected randomly from Gomori stained sections using x20 objective. ISFC-ratio increased with Gleason pattern both for the entire group but also for "Necrotizing" phenotype patterns and "Solid" phenotype patterns, excepting the subtype "4A" where the stromal compartment was reduced by the expansion of tumoral ducts enlarged by growing tumoral intraductal cribriform masses.
These preliminary data showed that stromal microenvironment try to adapt to the loss of tumoral differentiation by increasing the amount of fibrillary components of intratumoral stromal compartment.
The vascular layers on the rostral ventrolateral medulla M. Motoc There has been a keen interest in assessing the neurovascular anatomy of the rostral ventrolateral medulla oblongata RVLM.
The present study was aimed at documenting the complete neurovascular anatomy of the RVLM, in order to offer a general picture of the possible offending vessels of this area, which seems to be involved in the pathogeny of the essential hypertension. Noteworthy, syndromes of the last cranial nerves could be due to vascular contacts or compressions. The present study was performed on 20 human adult brainstem-cerebellum blocks, dissected out of the posterior cerebral fossa at autopsies.
Within that space, three vascular layers were identified: a superficial one, formed by the inferior cerebellar arteries, a middle one, consisting of perforating arteries, and a deep, venous one. Microanatomical studies of the vascular relations of the RVLM are able to complete the somewhat ovarian cancer remission findings of studies based on imaging techniques.
The offending vessels of the RVLM could be any of the vessels inside the quadrilateral space. The perforators and the venous layers in the quadrilateral space should also be better evaluated from this perspective.
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Margaritescu, O. Cotoi Chronic Obstructive Pulmonary Disease COPD is one of the leading causes of morbidity and mortality in the industrialized and in the developing countries. It is believe, at least in part, that some of the structural changes that occur in COPD would be a result of epidermal ovarian cancer remission factors EGFs and their receptors. Therefore, our study aims was to examine the expression patterns of EGF and their receptors EGFR1 and c-erbB2 in the bronchial mucosa from the biopsy specimens harvested from smoking and non-smoking CB patients, compared with their expression in normal controls.
Regarding cellular localization and staining pattern, we noticed a cytoplasmic and nuclear immunostaining for EGF in bronchial epithelium both for control and CB subjects at the level of basal and ciliated cells. For the receptors, reactions were at the membrane level especially at the lower lateral junctions between ciliated cells and their junctions with basal cells.
This reactivity proved the pathogenic implication of the EGF ovarian cancer remission their receptors in patients with CB and suggests that blockade of the EGFR pathway can be an alternative successful therapy. The immunohistochemical expression of p53 and Ki67 in ovarian epithelial borderline tumors.
You got a metastatic tumor in your brain that's appeared.
Correlation with clinicopathological factors Luminita Nicoleta Giurgea, Carmen Ungureanu, Maria Sultana Mihailovici Background: Borderline tumor of the ovary is an epithelial tumor with a low rate of growth and a low malignant potential to invade or metastasize.
This tumor often is associated with a significantly better prognosis than epithelial ovarian cancer. Most of these tumors are either serous or mucinous in histology.
Aim: Assessment of p53 and Ki67 immunohistochemical expression in 52 epithelial ovarian tumors, correlation with clinicopathological factors, and comparison between results in benign, borderline, and malignant tumors.
Materials and Methods: From ovarian cancer remission total number of patients diagnosed with epithelial ovarian neoplasms in the period52 operated patients were selected, with serous and mucinous tumors. Results: P53 immunoreactions were positive in Ki67 was positive in Ki67 immunoreactions were also positive in borderline and benign tumors, with lower percents, Conclusions: We found almost similar frequency of immunostaining in borderline tumors and low-grade invasive serous carcinomas in contrast to the significantly higher frequency of p53 mutations in high-grade serous carcinomas.
Proliferative activity as assessed by Ki67 staining does not explain any possible relationship of serous borderline tumors to epithelial ovarian cancer.
Margaritescu, Cristiana Eugenia Simionescu, A. Stepan Among the benign epithelial odontogenic tumors, the ameloblastoma occupies a special place because of their local aggressive behavior with devastating jaw destructions, which lead to a high ovarian cancer remission rate, even following the radical surgery. In an attempt to clarify the mechanisms underlying this behavior we immunohistochemically investigated the reactivity of different histological variant of ameloblastoma to MMP-9, TIMP-2, E-cadherin and vimentin.
A semiquantitative assessment of their reactivity in the epithelial neoplastic compartment was done and statistical correlation was attempt with histological variant and between them.
The MMP-9 and TIMP-2 reactivity was observed with variable intensity both in the neoplastic epithelium and in the stroma that surround the ameloblastic proliferations.